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Uday Shetty (Nana Patekar), Majnu (Anil Kapoor), and their boss, Sikander (Feroz Khan), the three Hong Kong-based serio-comic mobsters, are keen to get their sister Sanjana (Katrina Kaif) married into a respectable family.

Uday, upon a chance meeting with a handsome bachelor, Rajiv (Akshay Kumar), is convinced that the latter would be an appropriate match for Sanjana. However, Rajiv's uncle, Dr. Ghungroo (Paresh Rawal) does not approve of his nephew's acciociation with a dubious family.

Meanwhile, Sanjana, unaware of her brothers' contrivances, meets Rajiv on a cruise and the two fall in love. She has the acceptance of Dr. Ghungroo, who doesn't realize that she is the sister of the Mafia. 

When Dr. Ghungroo realizes his faux pas he tries to escaping the fury of the brothers. Hilarity ensues as each of theb diametrically different brothers begins engaging in smart and engagingly comic stunts to get the uncle to agree to the alliance. 

This fall-down funny comedy takes another turn when a stunning bomb (Mallika Sherawat) who claims to be Rajiv's fiancee shows up on the scene and adds to the commotion and mayhem.